all publications
Orphan quality control by an SCF ubiquitin ligase directed to pervasive C-degrons
Kong KYE*#, Shankar S*,Rühle F, Khmelinskii A#
Nature Communications 2023 pubmed biorxiv code data
Multiple quality control mechanisms monitor yeast chitin synthase folding in the endoplasmic reticulum
Sanchez N, de Leon N, Valle R, Fung JJ, Khmelinskii A, Roncero C#
Molecular Biology of the Cell 2023 pubmed
Multiplexed protein stability (MPS) profiling of terminal degrons using fluorescent timer libraries in Saccharomyces cerevisiae
Reinbold C, Kong KYE, Kats I, Khmelinskii A, Knop M#
Methods in Enzymology 2023 pubmed
Building yeast libraries to dissect terminal degrons with fluorescent timers
Kong KYE, Reinbold C, Knop M, Khmelinskii A#
Methods in Enzymology 2023 pubmed
Genetic requirements for repair of lesions caused by single genomic ribonucleotides in S phase
Schindler N*#, Tonn M*, Kellner V, Fung JJ, Lockhart A, Vydzhak O, Juretschke T, Möckel S, Beli P, Khmelinskii A, Luke B#
Nature Communications 2023 pubmed biorxiv code
SWR1 chromatin remodeling complex prevents mitotic slippage during spindle position checkpoint arrest
Caydasi AK, Khmelinskii A, Darieva Z, Kurtulmus B, Knop M, Pereira G#
Molecular Biology of the Cell 2023 pubmed biorxiv
Up-regulation of ubiquitin-proteasome activity upon loss of NatA-dependent N-terminal acetylation
Kats I, Reinbold C, Kschonsak M, Khmelinskii A, Armbruster L, Ruppert T, Knop M#
Life Science Alliance 2022 pubmed biorxiv
High-throughput analysis of protein turnover with tandem fluorescent protein timers
Fung JJ*, Blöcher-Juárez K*, Khmelinskii A#
Methods in Molecular Biology 2022 pubmed
Quality control of mislocalized and orphan proteins
Kong KYE, Coelho JPL, Feige MJ, Khmelinskii A#
Experimental Cell Research 2021 pubmed
Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase
Kong KYE*, Fischer B*, Meurer M*, Kats I, Li Z, Rühle F, Barry JD, Kirrmaier D, Chevyreva V, San Luis BJ, Costanzo M, Huber W, Andrews BJ, Boone C, Knop M#, Khmelinskii A#
Molecular Cell 2021 pubmed
Exploring whole-genome duplicate gene retention with complex genetic interaction analysis
Kuzmin E*, VanderSluis B*, Nguyen Ba AN, Wang W, Koch EN, Usaj M, Khmelinskii A, Usaj MM, van Leeuwen J, Kraus O, Tresenrider A, Pryszlak M, Hu MC, Varriano B, Costanzo M, Knop M, Moses A, Myers CL#, Andrews BJ#, Boone C#
Science 2020 pubmed
(Photo)convert to pooled visual screening
Ivanova E, Khmelinskii A#
Molecular Systems Biology 2020 pubmed
Ubc13-Mms2 cooperates with a family of RING E3s in membrane protein sorting
Renz C, Albanèse V, Tröster V, Albert TK, Santt O, Jacobs SC, Khmelinskii A, Léon S, Ulrich HD#
Journal of Cell Science 2020 pubmed biorxiv
Cooperation of mitochondrial and ER factors in quality control of tail-anchored proteins
Dederer V, Khmelinskii A, Huhn AG, Okreglak V, Knop M, Lemberg MK#
Elife 2019 pubmed
Genome-wide C-SWAT library for high-throughput yeast genome tagging
Meurer M*, Duan Y*, Sass E*, Kats I, Herbst K, Buchmuller BC, Dederer V, Huber F, Kirrmaier D, Štefl M, Van Laer K, Dick TP, Lemberg MK, Khmelinskii A#, Levy ED#, Knop M#
Nature Methods 2018 pubmed biorxiv
Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins
Kowalski L*, Bragoszewski P*#, Khmelinskii A, Glow E, Knop M, Chacinska A#
BMC Biology 2018 pubmed
Mapping degradation signals and pathways in a eukaryotic N-terminome
Kats I, Khmelinskii A, Kschonsak M, Huber F, Knieß RA, Bartosik A, Knop M#
Molecular Cell 2018 pubmed
Upregulation of SPS100 gene expression by an antisense RNA via a switch of mRNA isoforms with different stabilities
Bunina D*, Štefl M*, Huber F*, Khmelinskii A, Meurer M, Barry JD, Kats I, Kirrmaier D, Huber W, Knop M#
Nucleic Acids Research 2017 pubmed
Temporal and compartment-specific signals coordinate mitotic exit with spindle position
Caydasi AK, Khmelinskii A, Duenas-Sanchez R, Kurtulmus B, Knop M, Pereira G#
Nature Communications 2017 pubmed
Protein abundance control by non-coding antisense transcription
Huber F*, Bunina D*, Gupta I, Khmelinskii A, Meurer M, Theer P, Steinmetz LM, Knop M#
Cell Reports 2016 pubmed
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy
Yofe I*#, Weill U*, Meurer M, Chuartzman S#, Zalckvar E, Goldman O, Ben-Dor S, Schütze C, Wiedemann N, Knop M, Khmelinskii A#, Schuldiner M#
Nature Methods 2016 pubmed
Incomplete proteasomal degradation of green fluorescent proteins in the context of tandem fluorescent protein timers
Khmelinskii A, Meurer M, Ho CT, Besenbeck B, Füller J, Lemberg MK, Bukau B, Mogk A, Knop M#
Molecular Biology of the Cell 2016 pubmed biorxiv
Protein quality control at the inner nuclear membrane
Khmelinskii A*, Blaszczak E*, Pantazopoulou M, Fischer B, Omnus DJ, Le Dez G, Brossard A, Gunnarsson A, Barry JD, Meurer M, Kirrmaier D, Boone C, Huber W, Rabut G#, Ljungdahl PO#, Knop M#
Nature 2014 pubmed
A memory system of negative polarity cues prevents replicative aging
Meitinger F, Khmelinskii A, Morlot S, Kurtulmus B, Palani S, Andres-Pons A, Hub B, Knop M, Charvin G, Pereira G#
Cell 2014 pubmed
Analytical model for macromolecular partitioning during yeast cell division
Kinkhabwala A#, Khmelinskii A, Knop M#
BMC Biophysics 2014 pubmed
Analysis of protein dynamics with tandem fluorescent protein timers
Khmelinskii A, Knop M
Methods in Molecular Biology 2014 pubmed
Directional tissue migration through a self-generated chemokine gradient
Donà E, Barry JD, Valentin G, Quirin C, Khmelinskii A, Kunze A, Durdu S, Newton LR, Fernandez-Minan A, Huber W, Knop M, Gilmour D#
Nature 2013 pubmed
Tandem fluorescent protein timers for in vivo analysis of protein dynamics
Khmelinskii A*, Keller PJ*, Bartosik A§, Meurer M§, Barry JD§, Mardin BR, Kaufmann A, Trautmann S, Wachsmuth M, Pereira G, Huber W, Schiebel E#, Knop M#
Nature Biotechnology 2012 pubmed
Artificial tethering to nuclear pores promotes partitioning of extrachromosomal DNA during yeast asymmetric cell division
Khmelinskii A, Meurer M, Knop M#, Schiebel E#
Current Biology 2011 pubmed
Seamless gene tagging by endonuclease-driven homologous recombination
Khmelinskii A*, Meurer M*, Duishoev N, Delhomme N, Knop M#
PLoS One 2011 pubmed
Segregation of yeast nuclear pores
Khmelinskii A, Keller PJ, Lorenz H, Schiebel E#, Knop M#
Nature 2010 pubmed
Cell cycle control of spindle elongation
Roostalu J, Schiebel E, Khmelinskii A#
Cell Cycle 2010 pubmed
Phosphorylation-dependent protein interactions at the spindle midzone mediate cell cycle regulation of spindle elongation
Khmelinskii A*, Roostalu J*, Roque H, Antony C, Schiebel E#
Developmental Cell 2009 pubmed
Chromosome segregation: monopolin goes spindle
Khmelinskii A, Schiebel E#
Current Biology 2009 pubmed
Assembling the spindle midzone in the right place at the right time
Khmelinskii A, Schiebel E#
Cell Cycle 2008 pubmed
Cdc14-regulated midzone assembly controls anaphase B
Khmelinskii A*, Lawrence C*, Roostalu J, Schiebel E#
Journal of Cell Biology 2007 pubmed